BDBM50320226 CHEMBL1085240::N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-4-(trifluoromethyl)benzamide

SMILES CN1CCN(CC1)c1cccc(c1)-c1cnn2c(N)c(cnc12)-c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1

InChI Key InChIKey=PHVRYQBXECZHNT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50320226   

TargetTyrosine-protein kinase Lck(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320226(N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50: 23nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320226(N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50: 295nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320226(N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50: 323nMAssay Description:Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320226(N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320226(N-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed