BDBM50320228 4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenol::CHEMBL1083092

SMILES CN1CCN(CC1)c1ccc(cc1)-c1cnn2c(N)c(cnc12)-c1ccc(O)cc1

InChI Key InChIKey=WSGHPGAVEJYWCS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50320228   

TargetTyrosine-protein kinase Lck(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320228(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 36nMAssay Description:Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320228(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 85nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320228(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 396nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320228(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed