BDBM50320970 2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic acid(5-methyl-isoxazol-4-ylmethyl)-amide::CHEMBL1164264

SMILES Cc1oncc1CNC(=O)c1ccc2cc([nH]c2c1)-c1n[nH]cc1-c1ccccc1

InChI Key InChIKey=XLUGFNKYTODIAP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50320970   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320970(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 400nMAssay Description:Inhibition of GST-tagged full length CDK2/Cyclin E after 40 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320970(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 630nMAssay Description:Inhibition of GST-tagged full length recombinant ITK after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320970(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of GST-tagged full length GSK3-beta assessed as inhibition of ATP consumption after 60 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320970(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of GST-tagged recombinant INSR catalytic domain expressed in baculovirus-infected Sf21 cells after 80 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed