BDBM50321004 (R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(4-isopropylthiazol-2-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamide::CHEMBL1165653

SMILES CC(C)c1csc(NC(=O)[C@H](CC2CCOCC2)c2ccc(cc2)S(=O)(=O)C2CC2)n1

InChI Key InChIKey=BPQYAGOLJHAJOW-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50321004   

TargetHexokinase-4(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50321004((R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(4-isoprop...)
Affinity DataEC50:  26nMAssay Description:Induction of glucokinase-mediated 2-deoxy-D-[3H]glucose uptake in Sprague-Dawley rat hepatocytes after 4 hrs by liquid scintillation countinglMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50321004((R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(4-isoprop...)
Affinity DataEC50:  26nMAssay Description:Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50321004((R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(4-isoprop...)
Affinity DataEC50:  157nMAssay Description:Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed