BDBM50321052 CHEMBL1163567::{1-[(5-Chloro-2-trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}-(4-methoxy-piperidin-1-yl)-methanone

SMILES COC1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc2NCCN(Cc3cc(Cl)ccc3C(F)(F)F)c2c1

InChI Key InChIKey=VMVVOKCTJMCBIB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50321052   

TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50321052({1-[(5-Chloro-2-trifluoromethyl)benzyl]-1,2,3,4-te...)
Affinity DataIC50: 40nMAssay Description:Inhibition of ALK by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50321052({1-[(5-Chloro-2-trifluoromethyl)benzyl]-1,2,3,4-te...)
Affinity DataIC50: 450nMAssay Description:Inhibition of ALK phosphorylation in human Karpas-299 cells by immunoblotting and ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed