BDBM50322183 3-(4-ethylphenylsulfonyl)-N-(3-methoxypropyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine::CHEMBL1173569::UT-A1 inhibitor D4

SMILES CCc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCCCOC)nc12

InChI Key InChIKey=RIOVEEIJMAIHQH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50322183   

TargetUrea transporter 2(Rat)
University of California San Francisco

LigandPNGBDBM50322183(CHEMBL1173569 | UT-A1 inhibitor D4 | 3-(4-ethylphe...)
Affinity DataIC50: 5.00E+4nMAssay Description:The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details Article
PubMed
TargetUrea transporter 1(Rat)
University of California San Francisco

LigandPNGBDBM50322183(CHEMBL1173569 | UT-A1 inhibitor D4 | 3-(4-ethylphe...)
Affinity DataIC50: 2.80E+4nMAssay Description:Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details Article
PubMed
TargetUrea transporter 1(Mouse)
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50322183(CHEMBL1173569 | UT-A1 inhibitor D4 | 3-(4-ethylphe...)
Affinity DataIC50: 212nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50322183(CHEMBL1173569 | UT-A1 inhibitor D4 | 3-(4-ethylphe...)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed