BDBM50322820 CHEMBL1172781::S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2-phenylethano

SMILES c1ccc(cc1)c2c3c(ncnc3oc2c4ccccc4)N[C@H](CO)c5ccccc5

InChI Key InChIKey=CCGBAJCQZPJWCS-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50322820   

TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 223nMAssay Description:Inhibition of GST-tagged EGFR expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 223nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 393nMAssay Description:Inhibition of human wild type GST-tagged EGFR kinase domain expressed in Sf9 cells by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 223nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50322820(S-2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)-2...)
Affinity DataIC50: 223nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)