BDBM50322905 CHEMBL1210351::CHEMBL1788375::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-2-yl)methylsulfonamido)benzamide::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-2-yl)methylsulfonamido)benzamide hydrobromide

SMILES CS(=O)(=O)N(c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)c1ccccn1

InChI Key InChIKey=NLBLQQZAHZCPKB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50322905   

TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 290nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 5.89E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 8.32E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 2.82E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed