BDBM50322907 CHEMBL1210353::CHEMBL1210357::N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-3-(N-(pyridin-4-yl)methylsulfonamido)benzamide hydrochloride

SMILES CS(=O)(=O)N(c1ccncc1)c1cccc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F

InChI Key InChIKey=SOGVSPVLCXEDPN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50322907   

TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 210nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 280nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 580nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed