BDBM50323264 6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpholinoethyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile::CHEMBL1208848

SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc2n(CCN3CCOCC3)cnc2c(n1)C#N

InChI Key InChIKey=IAWRDJJFHSITBE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323264   

TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323264(6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpho...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323264(6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpho...)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323264(6-(4-ethoxy-3-(trifluoromethyl)phenyl)-1-(2-morpho...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin S-mediated proteolytic cleavage of MHC2 associated invariant chain in human JY cells assessed as accumulation of lip10 by Wes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed