BDBM50323346 CHEMBL1209556::rac-4-Isobutyl-6-(4-trifluoromethyl-benzyl)-6,7-dihydro-5-thia-2,3a,6-triaza-indene 5,5-dioxide

SMILES CC(C)CC1n2cncc2CN(Cc2ccc(cc2)C(F)(F)F)S1(=O)=O

InChI Key InChIKey=CGIWGBIOKQVESP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323346   

TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323346(rac-4-Isobutyl-6-(4-trifluoromethyl-benzyl)-6,7-di...)
Affinity DataIC50: 121nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323346(rac-4-Isobutyl-6-(4-trifluoromethyl-benzyl)-6,7-di...)
Affinity DataIC50: 566nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323346(rac-4-Isobutyl-6-(4-trifluoromethyl-benzyl)-6,7-di...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed