BDBM50323654 CHEMBL1208829::N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide

SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C

InChI Key InChIKey=UUROSJLZNDSXRF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50323654   

TargetScavenger receptor class B member 1(Mouse)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50323654(N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phe...)
Affinity DataIC50: 770nMAssay Description:Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of [3H]cholesteryl ester uptake into cells after 2 to 3 hrs by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
TargetScavenger receptor class B member 1(Mouse)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50323654(N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phe...)
Affinity DataIC50: 770nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetScavenger receptor class B member 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323654(N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phe...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
K£Mia

Curated by ChEMBL
LigandPNGBDBM50323654(N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phe...)
Affinity DataIC50: 59nMAssay Description:Inhibition of p38 alpha activity by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
K£Mia

Curated by ChEMBL
LigandPNGBDBM50323654(N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phe...)
Affinity DataIC50: 38nMAssay Description:Inhibition of phospho-p38 alpha activity by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed