BDBM50325855 CHEMBL1223951::exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide

SMILES NC(=O)c1cccc(O[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c1

InChI Key InChIKey=NBLFFMILGMAYPO-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50325855   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataKi:  40nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 286nMAssay Description:Antagonist activity at human kappa opioid receptor assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 9.68E+3nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 1.07E+4nMAssay Description:Antagonist activity at human mu opioid receptor assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 2.74E+4nMAssay Description:Antagonist activity at human delta opioid receptor assessed as inhibition of SNC80-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human delta opioid receptor expressed in HEK cells assessed as inhibition of SNC-80-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed