BDBM50325859 CHEMBL1223955::endo-3-((R)-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl)sulfinyl)benzamide

SMILES NC(=O)c1cccc(c1)S(=O)[C@@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccccc1

InChI Key InChIKey=HQXYMUSPACPKSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50325859   

TargetKappa-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325859(endo-3-((R)-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]o...)
Affinity DataIC50: 8.24E+3nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325859(endo-3-((R)-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]o...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325859(endo-3-((R)-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]o...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human delta opioid receptor expressed in HEK cells assessed as inhibition of SNC-80-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed