BDBM50328037 CHEMBL1258466::N-((2S,3R)-4-(1-(4-tert-butylthiophen-2-yl)cyclohexylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)acetamide

SMILES CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(CCCCC1)c1cc(cs1)C(C)(C)C

InChI Key InChIKey=HPRGPIBWFPUGCR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50328037   

TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328037(N-((2S,3R)-4-(1-(4-tert-butylthiophen-2-yl)cyclohe...)
Affinity DataIC50: 32nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328037(N-((2S,3R)-4-(1-(4-tert-butylthiophen-2-yl)cyclohe...)
Affinity DataIC50: 104nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed