BDBM50328049 CHEMBL1257302::N-((2S,3R)-4-(1-(6-tert-butylpyrimidin-4-yl)cyclohexylamino)-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl)acetamide

SMILES CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(CCCCC1)c1cc(ncn1)C(C)(C)C

InChI Key InChIKey=VVWGMEIQTOBDML-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50328049   

TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(N-((2S,3R)-4-(1-(6-tert-butylpyrimidin-4-yl)cycloh...)
Affinity DataIC50: 245nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(N-((2S,3R)-4-(1-(6-tert-butylpyrimidin-4-yl)cycloh...)
Affinity DataIC50: 250nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(N-((2S,3R)-4-(1-(6-tert-butylpyrimidin-4-yl)cycloh...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(N-((2S,3R)-4-(1-(6-tert-butylpyrimidin-4-yl)cycloh...)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed