BDBM50328189 (4-(pyrrolidin-1-yl)piperazin-1-yl)(4-(4-(trifluoromethoxy)phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanone::CHEMBL1257541::US9670214, TABLE 13.12

SMILES FC(F)(F)Oc1ccc(Nc2ncnc3sc(cc23)C(=O)N2CCN(CC2)N2CCCC2)cc1

InChI Key InChIKey=WQHXIMCGFHBRFN-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328189   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50328189((4-(pyrrolidin-1-yl)piperazin-1-yl)(4-(4-(trifluor...)
Affinity DataEC50:  1.34E+3nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetNon-specific protein-tyrosine kinase(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328189((4-(pyrrolidin-1-yl)piperazin-1-yl)(4-(4-(trifluor...)
Affinity DataIC50: 1.34E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328189((4-(pyrrolidin-1-yl)piperazin-1-yl)(4-(4-(trifluor...)
Affinity DataIC50: 3.96E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent