BDBM50328755 2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)phenyl)acetamide::CHEMBL1271376

SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(n1)-c1cccc(CC(N)=O)c1

InChI Key InChIKey=ZJQYVSTVRXOFQL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50328755   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328755(2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328755(2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido...)
Affinity DataIC50: 9nMAssay Description:Binding affinity to unphosphorylated p38alpha by fluoroprobe binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328755(2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido...)
Affinity DataIC50: 11nMAssay Description:Binding affinity to phosphorylated p38alpha by fluoroprobe binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328755(2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido...)
Affinity DataIC50: 17nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328755(2-(3-(3-tert-butyl-5-(3-(2,3-dichlorophenyl)ureido...)
Affinity DataIC50: 82nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed