BDBM50329061 CHEMBL1270976::N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N4-methyl-N2-(3-(methylsulfonyl)phenyl)pyrimidine-2,4-diamine

SMILES CN(c1ccnc(Nc2cccc(c2)S(C)(=O)=O)n1)c1c2OCOc2ccc1Cl

InChI Key InChIKey=VPLVGQXSWQPIQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329061   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329061(N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N4-methyl-N2...)
Affinity DataIC50: 36nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329061(N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N4-methyl-N2...)
Affinity DataIC50: 42nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed