BDBM50329308 (R)-3-(5-Trifluoromethyl-[1,3,4]thiadiazol-2-ylamino)-pyrrolidine-1-carboxylic acid 5-carbamoyl-adamantan-2-yl ester::CHEMBL1271217

SMILES NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Nc1nnc(s1)C(F)(F)F)C(C3)C2

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50329308   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329308((R)-3-(5-Trifluoromethyl-[1,3,4]thiadiazol-2-ylami...)
Affinity DataIC50: 21.3nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329308((R)-3-(5-Trifluoromethyl-[1,3,4]thiadiazol-2-ylami...)
Affinity DataIC50: 100nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed