BDBM50329520 (R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1271450

SMILES CN1C(N)=N[C@](C1=O)(c1ccc(OCCF)cc1)c1cccc(c1)-c1cccnc1F

InChI Key InChIKey=IWNLEEUFYZWVMW-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50329520   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329520((R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-f...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329520((R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-f...)
Affinity DataEC50:  320nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329520((R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-f...)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329520((R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-f...)
Affinity DataIC50: 2.83E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed