BDBM50329573 (S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one::CHEMBL1270630

SMILES CN1C(N)=N[C@@](C1=O)(c1cccc(c1)C#CC1CC1)c1ccc(OC(F)F)c(C)c1

InChI Key InChIKey=PWZLUGHNDYWEDU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50329573   

TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetRenin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of renin by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed