BDBM50329821 1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-3-(3-methoxyphenyl)urea::CHEMBL1272135

SMILES COc1cccc(NC(=O)Nc2cccn(Cc3c(F)cccc3Cl)c2=O)c1

InChI Key InChIKey=VTQGIZQKCPGUNG-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50329821   

TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataKi:  25.1nMAssay Description:Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed