BDBM50330161 CHEMBL1272270::N-(4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)cyclopropanecarboxamide

SMILES CSc1nc(c(-c2ccnc(NC(=O)C3CC3)c2)n1C)-c1ccc(F)cc1

InChI Key InChIKey=PPLGDSLAUUXVNO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330161   

TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls University of TüBingen

Curated by ChEMBL
LigandPNGBDBM50330161(N-(4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1...)
Affinity DataIC50: 170nMAssay Description:Inhibition of p38alpha by immunosorbent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls University of TüBingen

Curated by ChEMBL
LigandPNGBDBM50330161(N-(4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1...)
Affinity DataIC50: 222nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) using ATF-2 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50330161(N-(4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1...)
Affinity DataIC50: 638nMAssay Description:Competitive inhibition of human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed