BDBM50331901 CHEMBL1289341::E-5-Bromo-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one

SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(Br)cc23)cc1

InChI Key InChIKey=PJOBZMKBVWXAHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331901   

TargetProstaglandin G/H synthase 1(Rabbit)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50331901(E-5-Bromo-3-[[4-(methylsulfonyl)phenyl]methylene]-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Rabbit)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50331901(E-5-Bromo-3-[[4-(methylsulfonyl)phenyl]methylene]-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed