BDBM50331906 2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6-yloxy)-N-(3,4-dichlorobenzyl)acetamide::CHEMBL1289344

SMILES Clc1ccc(CNC(=O)COc2ccc3[nH]c(=O)c(C#N)c(CCc4ccccc4)c3c2)cc1Cl

InChI Key InChIKey=WGKBQTPUQRZAOZ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331906   

TargetAdenosine receptor A2b(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331906(2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6...)
Affinity DataKi:  338nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331906(2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6...)
Affinity DataKi:  408nMAssay Description:Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331906(2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6...)
Affinity DataKi:  667nMAssay Description:Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331906(2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6...)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO-K1 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331906(2-(3-cyano-2-oxo-4-phenethyl-1,2-dihydroquinolin-6...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH58261 from human adenosine A2A receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed