BDBM50332304 (5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-yl)(2,6-difluorophenyl)methanone::CHEMBL1288032

SMILES Nc1nc(Nc2cccnc2)nn1C(=O)c1c(F)cccc1F

InChI Key InChIKey=OAKPDANQZXYWES-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50332304   

TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed