BDBM50332376 4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-carboxamide::CHEMBL1631468

SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1

InChI Key InChIKey=LHKDIYKHGIOMPL-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50332376   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332376(4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...)
Affinity DataEC50:  379nMAssay Description:Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332376(4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...)
Affinity DataEC50:  104nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332376(4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...)
Affinity DataEC50:  1.13E+3nMAssay Description:Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332376(4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...)
Affinity DataKi:  380nMAssay Description:Displacement of [3H]flunitrazepam from human alpha2beta3gamma2 GABA receptor in Sf9 membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed