BDBM50333570 2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamino)-5-chloro-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide::CHEMBL1642144

SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(C)=O)ncc1Cl

InChI Key InChIKey=WIXBTAOMGMZCEY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50333570   

TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50333570(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Affinity DataIC50: 28nMAssay Description:Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50333570(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Affinity DataIC50: 30nMAssay Description:Inhibition of c-Met expressed in human GTL-16 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50333570(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Affinity DataIC50: 500nMAssay Description:Inhibition of insulin receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed