BDBM50333845 (R)-2-(2,4-difluoro-7-(4-fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid::CHEMBL1643784

SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cc(F)cc(F)c3n2C1)S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=BPDFPUCEDRYHJW-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50333845   

TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333845((R)-2-(2,4-difluoro-7-(4-fluoro-N-methylphenylsulf...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333845((R)-2-(2,4-difluoro-7-(4-fluoro-N-methylphenylsulf...)
Affinity DataIC50: 9.90nMAssay Description:Antagonist activity at human recombinant CRTH2 receptor expressed in HEK293 cells assessed as inhibition of DK-PGD2-induced intracellular cAMP format...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333845((R)-2-(2,4-difluoro-7-(4-fluoro-N-methylphenylsulf...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of DK-PGD2-induced eosinophils shape changeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333845((R)-2-(2,4-difluoro-7-(4-fluoro-N-methylphenylsulf...)
Affinity DataKi:  427nMAssay Description:Binding affinity to thromboxane receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333845((R)-2-(2,4-difluoro-7-(4-fluoro-N-methylphenylsulf...)
Affinity DataKi:  711nMAssay Description:Binding affinity to prostanoid DP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed