BDBM50333849 (R)-2-(7-(N-(cyclopropylmethyl)-4-fluorophenylsulfonamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid::CHEMBL1643788

SMILES OC(=O)Cc1c2CC[C@H](Cn2c2ccccc12)N(CC1CC1)S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=ONYPZLDHENOVTO-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333849   

TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333849((R)-2-(7-(N-(cyclopropylmethyl)-4-fluorophenylsulf...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333849((R)-2-(7-(N-(cyclopropylmethyl)-4-fluorophenylsulf...)
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at human recombinant CRTH2 receptor expressed in HEK293 cells assessed as inhibition of DK-PGD2-induced intracellular cAMP format...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333849((R)-2-(7-(N-(cyclopropylmethyl)-4-fluorophenylsulf...)
Affinity DataKi:  130nMAssay Description:Binding affinity to prostanoid DP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333849((R)-2-(7-(N-(cyclopropylmethyl)-4-fluorophenylsulf...)
Affinity DataKi:  1.22E+3nMAssay Description:Binding affinity to thromboxane receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed