BDBM50334234 (S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-benzo[d]imidazol-1-yl)-N,2-dicyclohexylacetamide::CHEMBL1642362

SMILES Fc1cc2nc(-c3ccc(Cl)cc3)n([C@@H](C3CCCCC3)C(=O)NC3CCCCC3)c2cc1Cl

InChI Key InChIKey=IDVWFRRQOFXIBN-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50334234   

TargetBile acid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataEC50:  141nMAssay Description:Agonist activity at human FXR expressed in cells assessed as transactivation by luciferase transcriptional reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50: 13nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50: 13nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBile acid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at Gal4-fused human FXR by luciferase reporter gene transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed