BDBM50334455 CHEMBL1643900::N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4.0.02,6.03,10.05,9]undecane

SMILES Fc1cccc(CCN[C@@H]2C3C4CC5C6CC(C3C46)C25)c1

InChI Key

Data  17 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50334455   

TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  19nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat PC12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  705nMAssay Description:Inhibition of muscarinic M4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  1.68E+3nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  1.83E+3nMAssay Description:Inhibition of muscarinic M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  2.29E+3nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  2.38E+3nMAssay Description:Inhibition of H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  2.38E+3nMAssay Description:Inhibition of histamine H1 receptor (unknown origin) by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  3.62E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  4.42E+3nMAssay Description:Inhibition of histamine H2 receptor (unknown origin) by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  4.42E+3nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  5.22E+3nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  6.02E+3nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  6.98E+3nMAssay Description:Inhibition of 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi:  7.61E+3nMAssay Description:Inhibition of alpha2A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50334455(N-(2-(3'-Fluorophenyl)ethyl)-8-aminopentacyclo[5.4...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed