BDBM50334674 CHEMBL1642594::N-cyclopropyl-N-((4R)-4-(methylsulfonamidomethyl)-4-phenylcyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](CNS(C)(=O)=O)(CC1)c1ccccc1)C(F)(F)F

InChI Key InChIKey=KVTMYUXPWDQIDC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50334674   

LigandPNGBDBM50334674(N-cyclopropyl-N-((4R)-4-(methylsulfonamidomethyl)-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human full length 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50334674(N-cyclopropyl-N-((4R)-4-(methylsulfonamidomethyl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in human adipocytes assessed as inhibition of conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50334674(N-cyclopropyl-N-((4R)-4-(methylsulfonamidomethyl)-...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50334674(N-cyclopropyl-N-((4R)-4-(methylsulfonamidomethyl)-...)
Affinity DataIC50: 259nMAssay Description:Inhibition of human recombinant full length 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of conversion of [3H]cortisone to [3H]cortis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed