BDBM50334765 CHEMBL1642895::trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine

SMILES CN[C@H]1C[C@H](c2ccc(Cl)c(Cl)c2)c2ccccc2C1

InChI Key InChIKey=KDERKEZKMQCRPQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50334765   

TargetSodium-dependent dopamine transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 62nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 117nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 125nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 5.26E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(trans-(2S,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed