BDBM50334857 3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)-6-(prop-1-ynyl)pyrazolo[1,5-a]pyrimidin-7-amine::CHEMBL1643211

SMILES CC#Cc1c(N)n2ncc(-c3cnn(C)c3)c2nc1C1CCCNC1

InChI Key InChIKey=USJSFMYGTKDXFG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50334857   

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334857(3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)-6-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334857(3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)-6-...)
Affinity DataIC50: 520nMAssay Description:Inhibition of recombinant CDK2/Cyclin A expressed in insect Sf9 cells assessed as inhibition of [33P]-ATP incorporation into biotinylated histone H1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed