BDBM50335495 4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl methanesulfonate::CHEMBL1651842::US10357546, JNMS-38

SMILES CS(=O)(=O)Oc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1

InChI Key InChIKey=IEHSRERHOYOHOA-UHFFFAOYSA-N

Data  16 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50335495   

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  5nMAssay Description:Competitive inhibition of human MMP9 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  5nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  5nMAssay Description:Competitive inhibition of human MMP-9 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  23nMAssay Description:Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  23nMAssay Description:Competitive inhibition of human MMP-2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  145nMAssay Description:Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  150nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  575nMAssay Description:Competitive inhibition of human MMP3 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  600nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  1.40E+3nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetMatrilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of human recombinant MMP7 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  1.82E+4nMAssay Description:Competitive inhibition of human MMP7 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition of human recombinant MMP1 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335495(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl me...)
Affinity DataKi:  1.40E+5nMAssay Description:Competitive inhibition of human MMP1 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed