BDBM50336317 CHEMBL1667935::cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-1-methylcyclobutanol::cis-3-[4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-methyl-cyclobutanol

SMILES C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2F)-c2ccccc2)c2c(N)ncnn12

InChI Key InChIKey=SCJMHNYQTKWNRD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50336317   

TargetInsulin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)i...)
Affinity DataIC50: 76nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50336317(cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)i...)
Affinity DataIC50: 17nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)i...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)i...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)i...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50336317(cis-3-[4-Amino-5-(8-fluoro-2-phenylquinolin-7-yl)i...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed