BDBM50336461 (S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::CHEMBL1668419

SMILES COc1cc(O)c2c(CCCCCC(=O)C=CC[C@H](C)OC2=O)c1

InChI Key InChIKey=JWTUFAOHKVRJNA-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50336461   

TargetVascular endothelial growth factor receptor 3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 720nMAssay Description:Inhibition of human recombinant VEGFR3 in cell free system after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant PDGFRbeta expressed in insect cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human recombinant VEGFR1 expressed in Sf9 cells after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant c-kit kinase in cell free system after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant ERK2 expressed in E.coli after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human recombinant PDGFRalpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant ERK1 expressed in E.coli after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant FLT-3 kinase expressed in insect cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant GSK3alpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in Sf9 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336461((S,E)-16-hydroxy-14-methoxy-3-methyl-3,4,9,10,11,1...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant MEK1 expressed in insect cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed