BDBM50336946 1-((4-(5-(2-Fluorobenzyl)benzo[d]thiazol-2-yl)-3-fluorophenyl)methyl)azetidine-3-carboxylic acid::CHEMBL1672558

SMILES OC(=O)C1CN(Cc2ccc(-c3nc4cc(Cc5ccccc5F)ccc4s3)c(F)c2)C1

InChI Key InChIKey=GVXGVDIXINMAAL-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50336946   

TargetSphingosine 1-phosphate receptor 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336946(1-((4-(5-(2-Fluorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataEC50:  3.47E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336946(1-((4-(5-(2-Fluorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336946(1-((4-(5-(2-Fluorobenzyl)benzo[d]thiazol-2-yl)-3-f...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed