BDBM50336974 CHEMBL1672611::N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide

SMILES O=C(Nc1cnc(-c2ccncc2)c(n1)-c1ccco1)C1CC1

InChI Key InChIKey=RZDRIXVHILKLLP-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50336974   

TargetAdenosine receptor A2b(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HeLa cells after 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataKi:  398nMAssay Description:Displacement of [3H]NECA from human adenosine A3 receptor expressed in HeLa cells after 3 hrs by filtration binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50336974(N-[6-(2-Furyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopro...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed