BDBM50337330 5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole::CHEMBL1682352::US9163007, 10

SMILES Fc1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)cc1

InChI Key InChIKey=GMPRARRULJWWPH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50337330   

LigandPNGBDBM50337330(5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Affinity DataKi:  56.3nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337330(5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Affinity DataKi:  70nMAssay Description:Inhibition of GSK3-beta after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337330(5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Affinity DataKi:  285nMAssay Description:Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337330(5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Affinity DataKi:  1.65E+5nMAssay Description:Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed