BDBM50337635 1-benzyl-1-(biphenyl-3-ylmethyl)-3-isopropylurea::CHEMBL1683191

SMILES CC(C)NC(=O)N(Cc1ccccc1)Cc1cccc(c1)-c1ccccc1

InChI Key InChIKey=FQRNTSVPJPARKR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50337635   

TargetProstaglandin E synthase(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337635(1-benzyl-1-(biphenyl-3-ylmethyl)-3-isopropylurea |...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of mPGES1 in IL1-beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337635(1-benzyl-1-(biphenyl-3-ylmethyl)-3-isopropylurea |...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337635(1-benzyl-1-(biphenyl-3-ylmethyl)-3-isopropylurea |...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed