BDBM50337670 1-benzyl-3-isopropyl-1-(3-(phenylethynyl)benzyl)thiourea::CHEMBL1683228

SMILES CC(C)NC(=S)N(Cc1ccccc1)Cc1cccc(c1)C#Cc1ccccc1

InChI Key InChIKey=ZRRPWFGCNTYIRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50337670   

TargetProstaglandin E synthase(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337670(1-benzyl-3-isopropyl-1-(3-(phenylethynyl)benzyl)th...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of mPGES1 in IL1-beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337670(1-benzyl-3-isopropyl-1-(3-(phenylethynyl)benzyl)th...)
Affinity DataIC50: 43nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed