BDBM50337818 CHEMBL1683876::N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-ethylethanamine::US10562878, Compound 73

SMILES CCN(CC)CC1(CCCCC1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=ZXAIYPYVRUXIRT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50337818   

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of human recombinant serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant Norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 710nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetNeuroepithelial cell-transforming 1(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 15nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Rat)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337818(N-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)-N-eth...)
Affinity DataIC50: 6nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent