BDBM50337848 CHEMBL1681810::N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclohexyl)methanamine::US10562878, Compound 101

SMILES CN(C)CC1(CCCCC1)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=QIYANFXIRPCCFR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50337848   

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337848(N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclo...)
Affinity DataIC50: 96nMAssay Description:Inhibition of human recombinant serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337848(N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclo...)
Affinity DataIC50: 268nMAssay Description:Inhibition of human recombinant dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337848(N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclo...)
Affinity DataIC50: 529nMAssay Description:Inhibition of human recombinant Norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337848(N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclo...)
Affinity DataIC50: 96nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337848(N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclo...)
Affinity DataIC50: 529nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337848(N,N-dimethyl-1-(1-(4-(trifluoromethyl)phenyl)cyclo...)
Affinity DataIC50: 268nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent