BDBM50337909 (+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanamine::1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanamine::CHEMBL1684042::US10562878, Compound 2 E2

SMILES CC(N)C1(CCCCC1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=XAXLSVQFDZVYNG-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50337909   

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 69nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 69nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 167nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 170nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 180nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 316nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 320nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 320nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 406nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 410nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 540nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 540nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 543nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 770nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 821nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337909((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)ethanami...)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent