BDBM50338728 (3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-(dimethylamino)phenylcarbamate::CHEMBL1684356

SMILES C[C@@H]1[C@@H](OC(=O)Nc2ccc(cc2)N(C)C)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12

InChI Key InChIKey=JMROMRUWLLLAJR-UHFFFAOYSA-N

Data  1 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50338728   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338728((3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trime...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338728((3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trime...)
Affinity DataKi:  5.10nMAssay Description:Displacement of radiolabeled Dexamethasone from GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338728((3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trime...)
Affinity DataIC50: 8.40nMAssay Description:Transrepression activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338728((3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trime...)
Affinity DataIC50: 39nMAssay Description:Transrepression activity at GR expressed in NHDF cells assessed as IL-1beta-mediated IL-6 transcription by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338728((3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trime...)
Affinity DataEC50:  361nMAssay Description:Agonist activity at GR expressed in rat H4IIEC3 cells assessed as induction of PEPCK transactivation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed