BDBM50338733 (+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate::CHEMBL1684341

SMILES CNC(=O)O[C@@H]1[C@@H](C)c2c(F)c(c(F)cc2NC1(C)C)-c1cccc2c(Cl)c[nH]c12

InChI Key InChIKey=IDTNHWABXAOVGP-UHFFFAOYSA-N

Data  1 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50338733   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338733((+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-diflu...)
Affinity DataKi:  2.20nMAssay Description:Displacement of radiolabeled Dexamethasone from GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338733((+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-diflu...)
Affinity DataIC50: 12nMAssay Description:Transrepression activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338733((+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-diflu...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338733((+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-diflu...)
Affinity DataIC50: 52nMAssay Description:Transrepression activity at GR expressed in NHDF cells assessed as IL-1beta-mediated IL-6 transcription by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338733((+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-diflu...)
Affinity DataEC50:  463nMAssay Description:Agonist activity at GR expressed in rat H4IIEC3 cells assessed as induction of PEPCK transactivation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed