BDBM50339636 1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea Hydrochloride::CHEMBL1688889

SMILES CC(C)Oc1cccc(NC(=O)NC(=O)c2cc3c(C)nn(C)c3nc2N(C)CCN(C)C)c1

InChI Key InChIKey=MFORNGKVWCJAME-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50339636   

TargetC-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at CCR2 in human PBMC cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR1 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR1 in human PBMC cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR3 in human PBMC cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR1 in eosinophil cells assessed as inhibition of CCL11-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR3 in eosinophil cells assessed as inhibition of CCL11-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR4 in transfected in THP-1 cells assessed as inhibition of CCL17-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CXCR1 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CXCR2 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Mouse)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at CCR2 in mouse spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Rat)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at CCR2 in rat spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed